It is generally believed that liver fibrosis is irreversible, so antiviral treatment can only protect the liver tissue that is not yet fibrotic to a certain extent. Liver fibrosis suggests that the primary liver disease has a tendency to evolve to cirrhosis, and once it is clearly identified, corresponding treatments should be carried out in time for the primary disease. If it is caused by hepatitis virus infection, anti-viral treatment, such as oral entecavir and other liver-protecting treatments such as oral glycyrrhizic acid preparation, can be actively carried out under the guidance of specialized physicians. However, no matter pure antiviral treatment or combined with other treatments, they can only slow down the progress of liver fibrosis to a certain extent, but cannot reverse the already fibrotic liver. Antiviral therapy is ineffective if the liver fibrosis is not caused by viral infection, but by other causes such as fatty liver, alcoholic liver disease, autoimmune liver disease, etc. It is recommended that once liver fibrosis is diagnosed, consult a doctor in time to identify the cause of the disease and treat it accordingly to avoid delaying the disease.