The high indirect bilirubin of itraconazole is considered to be caused by poor lifestyle habits, side effects of drugs, hepatitis, etc. It can be treated by general treatment such as dietary modification, stopping medication, and medication such as entecavir and dicyclomine. 1. Poor lifestyle: usually due to long nights and overwork during the period of taking itraconazole, which leads to the destruction of red blood cells in the body, and then the situation of high indirect bilirubin occurs. You can improve the situation of high indirect bilirubin by adjusting your diet or routine. 2. Side effects of drugs: It is usually due to the long-term use of itraconazole, resulting in side effects of drugs, so that the liver function is affected, which in turn causes high indirect bilirubin. You should stop using it in time and go to the hospital to use the medicine correctly under the doctor’s guidance. 3. Hepatitis: it may be due to viral infections in the liver, etc., due to the stimulation of inflammation, so that the function of the liver decreases, the metabolism of bilirubin is impeded, thus causing the high indirect bilirubin of Itraconazole. Enticavir tablets and bisacodyl tablets can be taken as prescribed by the doctor to treat the condition, but they should be taken in isolation from itraconazole. If the indirect bilirubin is high when taking itraconazole, you should go to the hospital for examination and treatment under doctor’s supervision.