Quadruple therapy nausea and vomiting in addition to the consideration of nausea and vomiting caused by the primary disease, should also consider the drug side effects, it is recommended that antibiotic drugs are taken after meals, avoiding fasting, which can appropriately reduce the gastric mucosal irritation, and it is recommended to consult a professional doctor in a timely manner. Quadruple therapy is a clinical treatment for Helicobacter pylori, including a proton pump inhibitor such as omeprazole, a bismuth agent such as bismuth potassium citrate, and two antibiotics such as amoxicillin and metronidazole. Antibiotic drugs can cause some irritation to the gastric mucosa and can trigger nausea and vomiting symptoms. If nausea and vomiting occur after taking the medication, it is considered to be related to the side effects of the medication. It is recommended to take antibiotic drugs after meals, avoiding empty stomach, can reduce gastric mucosal stimulation. If the nausea and vomiting is not related to the medication, and the degree of nausea and vomiting is the same before and after taking the medication, it is considered that the primary disease has not been relieved, and it is recommended to continue to follow the doctor’s instructions to use the medication regularly, and to observe the effect of the treatment. Some patients have liver and kidney function damage, which can also cause nausea and vomiting. It is important to consult a doctor in time for the treatment of liver and kidney function damage. It is recommended that patients with stomach discomfort consult a professional doctor in time, and those with Helicobacter pylori infection may consider applying quadruple therapy. If there is nausea and vomiting, the cause should be identified before proceeding with the appropriate professional treatment.