Approximately 20% of patients with colon cancer already have metastases at the time of diagnosis, most commonly liver metastases. Treatment of primary colon tumors and liver metastases has been evolving and usually includes chemotherapy plus surgical resection. However, there is no definitive answer as to whether primary tumors and metastases should be resected simultaneously or in stages. In the latest Journal ofGastrointestinalSurgery article, researchers at the Mayo Clinic conducted a retrospective study analyzing the benchmarks of surgical practice for providing simultaneous surgical resection and separate resection of colorectal primary cancer and liver metastases in patients with stage IV colorectal cancer. A total of 43,408 patients were included in the study, of whom 6661 underwent liver resection alone, 35,825 underwent colorectal resection alone, and 922 underwent simultaneous resection. The major complications of simultaneous surgical resection varied and were related to the cumulative extent of liver and colorectal cancer cancer procedures. The risk of surgical procedures increases, with a subsequent increase in the risk of poor patient prognosis. Simultaneous surgical resection is safe for patients requiring only minimal hepatectomy.