Thyroid disorders that cause goiter include: i. Primary hyperthyroidism, when severe patients have a significantly enlarged neck, accompanied by symptoms of thyroid hypermetabolism, such as fear of heat, excessive sweating, panic attacks, weight loss, etc. Second, primary hypothyroidism, when the cause is Hashimoto’s thyroiditis, patients show a moderate enlargement of the thyroid gland with a tough texture. Clinical manifestations of hypothyroidism include coldness, weakness, drowsiness, unresponsiveness, facial swelling, anemia, pericardial and pleural effusions, etc. Third, iodine deficiency causes goiter. If the goiter is more serious, it will cause symptoms such as difficulty in swallowing and difficulty in breathing.