In principle, tadalafil tablets and loratadine can be taken together and no drug interactions will be found between the two. Tadalafil tablets are used to treat erectile dysfunction in men, and can inhibit cyclic guanosine monophosphate-specific phosphodiesterase 5, allowing cyclic guanosine monophosphate levels to rise, allowing the relaxation of smooth muscle, causing the cavernous body to fill with blood, and producing an effect. Loratadine is used to relieve the symptoms of urticaria and allergic rhinitis and is commonly used in anti-allergy therapy. Loratadine has a potent, selective antagonism of peripheral H1 receptors, with anti-allergic, antihistamine and anti-inflammatory effects. Based on their mechanism of action, clinically relevant trials and drug interactions, there is no drug reaction when they are used together. Tadalafil tablets and loratadine may occur during the use of headache and other adverse reactions, it is recommended to seek medical attention, under the guidance of a professional doctor, rational and standardized use of drugs.