In the new crown outbreak, the third vaccine is now mostly referred to as the novel coronavirus vaccine booster shot, with most side effects lasting less than 72 hours after the booster shot. The neocoronavirus vaccine booster, like other vaccines, is a prophylactic vaccine that is primarily used to protect against infection by the neocoronavirus. Like other vaccines, the body may experience discomfort after vaccination, only the symptoms vary depending on the individual’s constitution. There are mainly localized symptoms and systemic symptoms. 1. Localized symptoms: mainly redness, swelling, pain and nodules on the skin at the vaccination site. 2. Systemic symptoms: These include generalized weakness, fatigue, headache, myalgia, arthralgia, fever and chills. Usually these side effects are relatively few and mild. They can be tolerated by the general population, and most of them gradually disappear within 72 hours. The body’s resistance to the new coronavirus may increase after vaccination with the new coronavirus. It is recommended to actively vaccinate against the new coronavirus if there are no contraindications.