Unilateral thickening of the adrenal gland may be caused by adrenal gland hyperplasia or adrenal tumor. Unilateral adrenal gland thickening usually occurs during ultrasound examination of the kidneys. Unilateral adrenal gland thickening is considered to be caused by unilateral adrenal gland hyperplasia or adrenal tumors, etc. However, the specific causes need to be further examined, such as abdominal enhancement CT, nephritin, aldosterone measurement, etc. If it is caused by tumor, it needs to be clarified according to the pathology whether the tumor is benign or malignant. If it is caused by adrenal tumors, it is necessary to clarify whether the tumor is benign or malignant according to the pathology. It is recommended that patients with adrenal gland thickening should go to the hospital in time for consultation and active treatment under the guidance of doctors.