When taking isosorbide mononitrate tablets for headache, the drug should be discontinued in time. The drug is a vasodilator drug, mainly used to dilate coronary arteries, which is generally used in clinical treatment of atherosclerotic heart disease of coronary arteries, and also dilates peripheral small arteries and cerebral arteries. If the blood vessels in the brain are dilated, it can cause hypoperfusion in the brain, resulting in ischemic and hypoxic changes in the brain, and patients can experience headache, nausea and vomiting. If for the vertebrobasilar system ischemia and hypoxia, dizziness, nausea and ataxia can also occur, etc. If necessary, dilation therapy is performed, and the main drug commonly used clinically is hydroxyethyl starch, and also given to improve blood circulation and Chinese herbal medicine, which is generally applied clinically to Shuxin, Danshen and Safflower. It is also possible to improve cerebral metabolism, and the drugs commonly used in clinical practice are cytarabine, piracetam and cerebroprotein hydrolysate, etc.