Pain in the cheek area requires differentiating whether there is a rash on the cheek area. If nothing is growing on the face and it is purely flushed and painful, consider the possibility of epidermal irritant dermatitis, which is caused by skin damage due to exposure to chemicals and allergy-like substances, resulting in pain. If there are visible small blisters and red papules on the surface, consider the possibility of herpes zoster following infection with the varicella-zoster virus. If the face is visibly red, swollen, and painful, and the pain feels worse when touched with the hand, consider facial pain that develops after a bacterial infection. Each painful symptom is treated differently. If it is formed by allergic irritants, you can choose to use hyaluronic acid gel or other medications that have moisturizing and repairing properties to achieve the effect of getting rid of the pain. If it is shingles you need to opt for oral acyclovir tablets followed by topical acyclovir cream and with oral B-complex vitamins. If it is caused by bacterial infection, you need to choose oral or injectable antibiotics, followed by topical application of mupirocin ointment. The above treatment should be carried out under the guidance of a doctor.