Metformin extended-release tablets can be used in combination with acarbose, which needs to be judged according to the specific blood sugar situation. The glucose-lowering mechanisms of the two drugs are different, and so are the methods of taking the drugs. Metformin is recommended to be taken before or during meals, mainly to lower basal blood sugar, and acarbose is chewed during meals, mainly to lower postprandial blood sugar. Whether to combine metformin and acarbose need to determine whether the postprandial blood glucose is higher than normal, if higher than normal, then acarbose can be combined. Common adverse effects of metformin include gastrointestinal discomfort, fatigue, etc. In severe cases, lactic acidosis may occur. Whereas, the adverse effects of acarbose are commonly associated with gastrointestinal side effects such as flatulence and diarrhea, and edema. Metformin is mainly contraindicated in people with type 1 diabetes mellitus with ketoacidosis, hepatic and renal insufficiency, cardiac failure, acute myocardial infarction, severe infection and trauma, major surgery, clinical conditions of hypotension and hypoxia, people with a previous history of lactic acidosis, and those who are allergic to the product are prohibited. Acarbose is mainly contraindicated in people who are allergic to Acarbose and/or inactive ingredients, chronic gastrointestinal disorders with significant digestive and absorption disorders, patients with disorders that may worsen due to intestinal flatulence (e.g., severe hiatus hernia, intestinal obstruction, and ulcers), and in patients with severe renal impairment. It is recommended that the combination of drugs under the guidance of a doctor, while paying attention to the monitoring of blood glucose to avoid hypoglycemia phenomenon, do not use drugs privately to avoid adverse reactions, while complying with the doctor’s instructions under the guidance of the doctor according to the blood glucose timely adjustment of the medication.