The main treatments for diffuse large B-cell lymphoma are chemotherapy, radiotherapy, bone marrow transplantation therapy, and surgery. Diffuse large B-cell lymphoma is a malignant tumor of B-cell origin and is an aggressive lymphoma, which is the most common type of malignant lymphoma in clinical practice. The recommended chemotherapeutic regimens vary depending on the stage of the disease. Clinical treatment is based on chemotherapy and combined with radiotherapy and surgery. 1. Chemotherapy: targeted therapy combined with chemotherapy is the basic treatment, and the international guidelines recommend rituximab combined with CHOP program as the standard first-line treatment; for early-stage patients, chemotherapy can be given for 4-6 cycles; for late-stage patients, chemotherapy should be given for 6-8 cycles. 2. radiotherapy: for early stage diffuse large B-cell lymphoma, local radiotherapy can be adopted after chemotherapy to consolidate the therapeutic effect and further reduce the recurrence. 3. stem cell transplantation: those who are eligible for bone marrow transplantation, especially patients with relapsed or refractory diffuse large B-cell lymphoma, can be considered to undergo bone marrow hemopoietic stem cell transplantation. 3. Stem cell transplantation: those who are eligible for bone marrow transplantation, especially patients with relapsed or refractory diffuse large B-cell lymphoma, can be considered for bone marrow hematopoietic stem cell transplantation. 4. Surgical treatment: for early stage patients, the purpose of surgical treatment is to obtain pathology and clear diagnosis; for patients with complications, such as digestive perforation, splenomegaly, which leads to the reduction of whole blood cells, surgical treatment can alleviate the symptoms and remove the complications. It is recommended that patients receive regular treatment in a timely manner, and should undergo regular review and lifelong follow-up after the completion of treatment, in order to obtain the best possible therapeutic effect and prolong life.