Closed-cell acne can be removed by topical medication, adjunctive therapy or with physical therapy. 1. Topical medication: Topical medication is the main method of treating closed mouth acne, which can be applied topically with all-trans retinoic acid cream, isotretinoin gel, and combined with benzoyl peroxide and azelaic acid to kill Propionibacterium acnes. Most patients can be removed by topical medication. 2. Adjuvant treatment: Use an acne squeezer under aseptic operation to squeeze out the contents of acne, or use chemical exfoliation therapy for treatment, such as fructose, salicylic acid, hydroxyacetic acid, etc., which can promote exfoliation of the stratum corneum and promote skin renewal. 3. Physical therapy: For some more serious patients, combined with photodynamic therapy can be used to inhibit sebum secretion, improve the formation of keratin at the mouth of the hair follicle, kill Propionibacterium acnes, and promote the recovery of the disease. The degree of each person’s condition is different, the treatment method is not the same, you should go to the hospital, under the guidance of the doctor to choose the appropriate method of removal, to avoid self-medication leading to adverse consequences.