Not all toothaches require medication, so there is no anti-inflammatory medication that works best for toothaches. Toothaches are most often caused by caries, periodontitis, erupting wisdom teeth, and splitting of teeth, and treatments vary. Commonly used anti-inflammatory drugs in dentistry include metronidazole, amoxicillin and cefixime. 1. Toothache caused by dental caries requires timely filling in the dentist, and root canal treatment if it has caused pulpitis. 2. periodontitis and other factors leading to toothache, you can follow the doctor’s instructions to take anti-inflammatory analgesic drugs for treatment, such as cefixime, metronidazole and so on. At the same time, periodontal treatment should be carried out, such as scaling to remove periodontal calculus and soft tartar and other irritating factors. 3. Wisdom teeth eruption caused by toothache, you can go to the stomatology department in time for local rinsing medicine, if necessary, follow the doctor’s instructions with metronidazole, amoxicillin, etc., oral, after the elimination of inflammation can be considered in accordance with the circumstances of the wisdom teeth extraction. 4. Toothache caused by tooth splitting, need to go to the stomatology department in time for dental restoration. It is recommended that patients with toothache symptoms should go to the stomatology department of the hospital in a timely manner to clarify the cause of the disease, and then take therapeutic measures, do not take anti-inflammatory drugs privately.