Chest pain in the middle of the chest can be seen in blood diseases, pleurisy, esophagitis, coronary heart disease, breast hyperplasia and so on. 1. Blood disease: blood disease such as leukemia patients, will appear sternal pain. 2. Pleurisy: the pleura is located on the inner surface of the chest wall, so patients suffering from pleurisy will also have symptoms of chest pain. 3. Esophagitis: the esophagus is located behind the sternum, so patients with esophagitis may also experience chest pain. 4. Coronary heart disease: patients with coronary heart disease often feel chest pain, accompanied by a sense of suffocation. 5. Breast Hyperplasia: Women with breast hyperplasia will also experience chest pain, which is more pronounced before the onset of menstruation. There are many reasons for chest pain, the above is just a list of a few of them, such as feeling chest pain in the middle of the chest, it is recommended to go to the hospital for further examination to clarify the cause of the pain, so as to treat the symptoms.