Whether blood creatinine 460μmol/L is serious or not mainly depends on its cause. If acute kidney injury causes creatinine elevation, creatinine may return to normal after correcting reversible factors, and it is usually not serious at this time; if chronic renal insufficiency causes creatinine elevation, serious complications such as hyperkalemia and acute left heart failure may occur, and it is more serious at this time. 1. Acute renal injury: if acute renal injury is caused by pre-renal factors such as volume insufficiency, renal artery stenosis, or post-renal factors such as urethral obstruction, and if creatinine level decreases gradually after correcting the reversible factors, it is usually not serious at this time; if the reversible factors cannot be corrected in time, chronic renal insufficiency may develop, which is more serious at this time. 2. Chronic renal insufficiency: If chronic renal insufficiency is caused by organic damage of glomerulus itself, the damage of kidney is usually irreversible. When creatinine 460μmol/L may appear hyperkalemia, acute left heart failure and other complications, serious cases can be life-threatening, this time is more serious. If patients find that the blood creatinine is elevated, it is recommended to go to regular hospitals in a timely manner, improve the examination to clarify the cause of the disease, and then give targeted treatment or treatment under the guidance of the doctor.