There is no harm in taking estrogen for a short period of time, but if it is taken for a long period of time, it will have a significant effect on the male reproductive system. In the clinic, boys take estrogen can be used to assist in the treatment of prostate hyperplasia and other diseases, and in a short period of time to take the body is not obviously harmful. However, if taken for a long period of time, it will make the estrogen in the male body too high, which will obviously affect the male reproductive system, such as affecting the level of androgens, so that men appear to have a thin voice, pitch and other feminized manifestations. It also triggers atrophy of testicular tissues and a decrease in the number of sperm in semen, leading to gynecomastia and endocrine disorders. Boys who need to use estrogen should take it under the guidance of a doctor, and need to master the dosage and the time of taking it to avoid adverse reactions.