Soreness in the front of the thigh, the possible causes are quadriceps injury, femoral neuritis, nerve entrapment, etc. The treatment includes general treatment, physical therapy, medication, surgery and so on. 1. Quadriceps injury: Soreness in the front of the thigh is mostly caused by strain or injury to the quadriceps muscle on the front side of the thigh, such as running, intense exercise, etc. It can be relieved after rest. Usually after rest can be relieved, can also be combined with hot compresses or physical therapy to help relieve. 2. Femoral neuritis: can cause symptoms of soreness in the front of the thigh, in addition to numbness, can choose neurotrophic drugs, such as vitamin B, methylcobalamin, etc. for treatment. 3. Nerve entrapment: such as lumbar intervertebral disc herniation, femoral nerve entrapment, lateral femoral cutaneous nerve entrapment, etc., which can produce radiating pain, manifested as soreness in the front of the thigh. When the pain is obvious, non-steroidal anti-inflammatory drugs such as celecoxib and ibuprofen can be used to relieve the symptoms, and when the condition is serious, surgery may be needed. The above medications need to be used under a doctor’s supervision. When the front of the thigh is sore and cannot be relieved after resting, it is recommended to consult a doctor in time to clarify the cause of the disease and receive appropriate treatment.