The causes of sore throat and pain on one side of the neck when swallowing saliva may include acute tonsillitis, acute pharyngolaryngitis, and soft tissue contusion of the neck, etc. Patients should choose the appropriate treatment, such as general treatment and medication, according to the different causes. 1. Acute tonsillitis: manifested as severe sore throat, the pain is aggravated when swallowing, so it will cause sore throat when swallowing and pain on one side of the neck. Patients should rest in bed, drink more water, eat light food, usually the symptoms are not serious will be relieved on their own, commonly used amoxicillin, cefaclor and other antibiotic treatment. 2. Acute pharyngolaryngitis: At the initial onset, patients will feel dry and burning in the throat, followed by obvious sore throat, and the pain will be aggravated when swallowing. Patients should keep their vocal cords well rested, and make no or fewer vocalizations. Patients can follow the doctor’s instructions to use the drug iodine glycerin, silver nitrate coated with the posterior wall of the pharynx for anti-inflammatory treatment. 3. Neck soft tissue contusion: it will cause subcutaneous tissue congestion, edema caused by pharyngeal pain, swallowing will pull the neck soft tissue, so it will aggravate the pain. Patients can follow the doctor’s instructions to take drugs ceftriaxone sodium, cefuroxime, cefixime and other treatment. If the symptoms of sore throat from swallowing saliva and pain on one side of the neck persist without relief, it is necessary to go to the hospital in time to make a clear diagnosis and standardize the use of medication and diagnosis and treatment, so as not to delay the condition.