Hands peeling but not painful and itchy may be related to physiological factors such as skin dehydration, or may be caused by diseases such as exfoliative keratolysis and malnutrition. 1. Physiological factors: if the skin is dehydrated or the climate is dry, it may lead to localized peeling, painless and itchy. 2. Exfoliative Keratolysis: its cause may be related to factors such as ringworm rash, excessive sweating and emotions, etc. Patients will have recurrent scaling and peeling on the hands and feet, usually without itching or pain. 3. Malnutrition: its etiology may be related to factors such as imbalance of proportion and insufficient nutritional intake, etc. Patients will mainly suffer from weight loss, emaciation and other symptoms, and some of them may be accompanied by dry skin, hyperkeratosis, flaking and other symptoms. There are many reasons that lead to hands peeling but not itchy, after excluding physiological factors, it is recommended that patients seek medical examination to clarify the cause of the disease and follow the doctor’s instructions for treatment.