Zoledronic acid is a common drug used to treat postmenopausal osteoporosis as well as deformational osteitis in women. Zoledronic acid is used to improve bone metabolism. Common side effects are causing generalized muscle soreness and bone pain, as well as a tendency to cause fever after using the drug, which also causes generalized muscle and bone pain that can be relieved in three to four days. Non-steroidal anti-inflammatory pain medications can be taken orally within half an hour of using Zolay Phosphate, most commonly ibuprofen to help relieve skeletal muscle pain caused by the use of Zolay Phosphate. It is important to check blood calcium when using this medication to make sure it is at a normal level to avoid hypocalcemia. It is also necessary to check creatinine clearance. Zoledronic acid should not be used when creatinine clearance is less than 35 ml/min. It is necessary to replenish body fluid before regular use of zoledronic acid.