Orlistat has a slow onset of action, usually taking more than 4 weeks to have a more pronounced effect, so eating twenty days of Orlistat did not lose weight may be a normal phenomenon, and need to pay attention to dietary factors, exercise factors and so on. Orlistat is suitable for long-term treatment of obesity and overweight people, the effect is usually slower, it takes more than 4 weeks to have a more obvious effect. When taking this product should minimize the intake of food with high fat content, light diet, balanced nutrition, appropriate reduction of carbohydrate intake, more fruits and vegetables. At the same time, attention should be paid to the combination of appropriate exercise, regular work and rest, to avoid excessive mental stress, in order to achieve a good effect of weight loss. The adverse reactions of this drug are mainly gastrointestinal reactions, such as abdominal pain, flatulence, soft stools, steatorrhea, and increased frequency of stools. Contraindications to the drug mainly include pregnant women, patients with hypersensitivity to orlistat or any of the components of the drug preparation, patients with chronic malabsorption syndrome, patients with organic obesity (eg, hypothyroidism). Orlistat should be regulated under the guidance of a doctor, do not increase or decrease the dosage without authorization, with a low-fat diet and exercise continued treatment to the target weight.