Prolonged sitting leading to sciatic nerve pain may be due to poor habits, but also may be caused by a number of secondary factors, such as lumbar disc herniation, sciatic tuberculosis, sacroiliac arthropathy, hip osteoarthritis and so on. At the same time, a few patients may be secondary to systemic diseases, such as diabetes mellitus, which generally requires drug therapy and lifestyle adjustments to intervene.1, poor habits: prolonged sitting is likely to cause muscle stiffness in the lower back and lower extremities, poor blood circulation, while the lower extremity blood supply is reduced, the reduction of the blood supply to the sciatic nerve can result in ischemia of the nerve and the emergence of pain, numbness and other symptoms. These patients through appropriate activities, promote blood circulation in the lower limbs, sciatic nerve pain symptoms can generally be gradually relieved; 2, lumbar disc herniation: sedentary can cause lumbar intervertebral disc herniated nucleus pulposus, the protruding nucleus pulposus stimulates the sciatic nerve will cause lower limb pain, numbness, activity limitation. At this time, patients need to bed rest, avoid weight bearing, pain is obvious can be used indomethacin, ibuprofen and other pain relievers, can also add vitamin B1, methylcobalamin and other neurotrophic agent treatment, but also can be applied to acupuncture, massage and other physical methods of treatment. For patients with poor effect of drug treatment or physical therapy and chronic recurrence, minimally invasive surgery can be considered to remove the protruding nucleus pulposus; 3, sciatic tuberculosis: prolonged sitting can also cause long-term friction and pressure on the bursa of sciatic tuberculosis, resulting in bursal congestion, edema, hyperplasia, resulting in aseptic inflammation of sciatic tuberculosis, the neighboring sciatic nerves can be stimulated and compressed, resulting in pain and numbness symptoms. At this time can be given ibuprofen, gabapentin pain treatment, can also be given to the local hot compresses, massage, and at the same time should be appropriate to strengthen the activities; 4, sacroiliac arthropathy: prolonged sitting is easy to cause the sacroiliac joints hyperplasia, stiffness, and the sciatic nerve can be stimulated by the joints of the hyperplasia and compression of the symptoms of pain. At this time, diclofenac sodium, ibuprofen can be given to relieve pain, but also can be given to local massage, hot compresses, acupuncture and other physical therapy to relieve; 5, hip arthritis: prolonged sitting is also easy to lead to the hip synovial capsule hyperplasia, sclerosis, which leads to the neighboring sciatic nerve by the hyperplasia of synovial capsule oppression and stimulation of the pain symptoms. Acute stage can be given a small dose of hormones, ibuprofen pain relief, but also through acupuncture, intermediate frequency pulsed electricity and other physical therapy to improve the symptoms; 6, diabetes: prolonged sitting is easy to cause reduced glycogen consumption, obesity can lead to insulin resistance, these factors can induce diabetes. And high blood sugar can cause ischemic degeneration of the sciatic nerve, resulting in pain, numbness symptoms. Generally, metformin can be given to reduce insulin resistance, or insulin can be given to control blood glucose, and at the same time to strengthen the exercise.