Liver and spleen lymphoma may be caused by liver abscess, viral hepatitis, leukemia and other diseases. 1. Liver abscess: it is a suppurative lesion of liver caused by various microorganisms such as bacteria, fungi or amoeba, which will lead to persistent pain in the liver area, which increases dramatically with deep breathing and body movement, liver and spleen lymphedema, and so on. 2. Viral hepatitis: it is an infectious disease caused by many kinds of hepatitis viruses with liver lesions as the main manifestation. Clinically, it is mainly manifested by loss of appetite, nausea, epigastric discomfort, pain in the liver area, fatigue, and liver and spleen lymphangiectasia. 3. Leukemia: it is a malignant clonal disease of hematopoietic stem-like progenitor cells due to biological, physical, chemical, genetic factors or other blood diseases, and clinically, it can be seen with different degrees of anemia, bleeding, infection, fever, as well as enlarged liver, spleen, lymph nodes, and bone pain and other symptoms. 4. Malignant tumor of liver: when suffering from malignant tumor of liver, such as primary liver cancer, lymphatic metastasis can lead to enlarged liver and spleen lymph nodes. Liver and spleen lymph node swelling may also be seen in lymphoma, tuberculosis tumor and other diseases, if liver and spleen lymph node swelling occurs, it is necessary to seek medical treatment in time.