Two plus signs positive for H. pylori indicate the presence of a certain amount of H. pylori in the patient’s body, but the number of H. pylori cannot be used alone as a basis for judging the severity of the disease. The severity of H. pylori infection is not only related to the number of H. pylori, but also to the virulence of the bacterial strain, the strength of the patient’s immunity, as well as the severity of his or her own disease, which requires a comprehensive judgment. If the patient is only infected with H. pylori, but not accompanied by or only have minor gastric ulcers, chronic gastritis, duodenal ulcers, etc., then it is not considered serious. If the patient is infected with H. pylori with severe peptic ulcer or with complications such as intestinal epithelial hyperplasia, it is a more serious phenomenon, and if persistent infection occurs, it may cause mucosa-associated lymphoid tissue lymphoma, and in severe cases, it may even lead to gastric cancer. The common clinical treatment for Helicobacter pylori is quadruple therapy, which generally involves the use of two antibiotics, such as clarithromycin and amoxicillin, a proton pump inhibitor, such as omeprazole or lansoprazole, and a medication that protects the gastric mucosa, such as bismuth pectin. They usually need to be taken for 10-14 consecutive days, with a review one month after stopping the medication. Infected with Helicobacter pylori, it is recommended that patients go to the hospital for treatment in a timely manner, and the use of drugs need to be taken under the guidance of a doctor on medical advice, so as not to cause harm to the body.