If a patient has sudden generalized aches and pains and weakness, it is usually due to the following factors: first, the pre-infection, the body if infected by bacteria, viruses or fungi and atypical pathogens, the body will release inflammatory mediators, usually leukotrienes, tumor necrosis factor, bradykinin, prostacyclin, such substances will release inflammatory factors in the body, inflammatory factors will lead to the clinical symptoms of generalized aches and pains and weakness. Secondly, sudden generalized aches and pains and weakness, also due to rhabdomyolysis diseases related to overdose, or summer heat stroke with heat cramps, heat exhaustion and pyrexia, will also appear sudden generalized aches and pains and weakness. Third, when common ion disorders, such as sudden onset of hypokalemia and hyponatremia, there will be clinical symptoms of sudden generalized aches and pains and weakness.