The five-year survival rate of moderately differentiated carcinoma of the rectum ranges from 10% to 90% after treatment, which is highly related to the stage. Rectal cancer is a common intestinal malignant tumor, which can be caused by poor dietary habits, heredity and other factors. Intermediate differentiation represents average differentiation of cancer cells, average malignancy and average prognosis. After diagnosis, the treatment is comprehensive treatment mainly based on surgical resection, and the specific prognosis after active treatment needs to be judged by clinical staging. Usually, the five-year survival rate of stage I rectal cancer after treatment is about 90%; stage II is about 70%; stage III is about 40%; and stage IV is only about 10%. In conclusion, the earlier the stage, the better the prognosis, so we should strive for early detection, early diagnosis and early treatment to obtain a better prognosis. It is recommended to consult the doctor in time and standardize the treatment for moderately differentiated rectal cancer so as to avoid delaying the condition.