Knee pain after running can be treated by paying attention to exercise time and weight bearing, local physical therapy, medication and surgical intervention. 1. When running, attention should be paid to avoid exceeding the load that one can bear, avoid long distance running, also avoid exercising in cold environment, avoid weight bearing as much as possible, training can choose limb elevation, such as: aerial cycling, bicycling, swimming and so on. 2. Local physical therapy, hot compresses can be used to promote local blood circulation and reduce pain and swelling. 3. Medication, if the pain is obvious, you can take non-steroidal anti-inflammatory drugs, such as ibuprofen, diclofenac sodium, celecoxib and so on. 4. Surgical intervention, if there is meniscus injury, further examination is needed, depending on the severity of the condition, arthroscopic surgical intervention. It is mainly caused by osteoarthritis of the knee, chondromalacia patella, meniscus injury and other diseases, please consult a professional physician for specific treatment. The medication should be prescribed by the doctor.