All antiepileptic drugs are associated with adverse effects to varying degrees and in different ways. Most drugs have toxic side effects that are much less severe than their antiepileptic effects and occur only in a small or very small number of patients. The vast majority of patients taking the medication are safe and do not experience these side effects. The first major category is the effect on the blood flow system, including a decrease in white blood cells, a decrease in platelets, or anemia, which is the suppression of blood cells. The second major category is the alteration of internal organs, often liver and kidney function. The third major category is the alteration of the central nervous system. The fourth major category is irritation of the digestive tract, such as nausea, vomiting, and abdominal pain. Most of the antiepileptic drug adverse reactions are transient and reversible, such as nausea, vomiting, headache, etc. mainly appear in the early stage of drug use, or appear when the dosage is large, for these cases as long as the use of small doses to start, gradually increase the dosage to the target agent, or gradually slow down the process of dosing, or only with the passage of time or dose stability, the symptoms will gradually reduce or even disappear. For the rash can be divided into two types, one is a mild rash related to the dose, which can also be reduced or disappeared by the above method; the other belongs to a severe rash, which should be immediately discontinued and actively treated in hospital; for liver damage, most of them can be relieved by just adding liver protection drugs, but severe damage requires antiepileptic drug reduction or even switching to other drugs to get better.