Syphilis late injection treatment generally refers to intramuscular injection of antibiotic drugs, if the oral drugs are also antibiotic drugs, the injection is not required to take orally, so as not to overdose; if the oral drugs are other drugs to improve the symptoms, or to increase the efficacy of antibiotics, the vast majority of cases are required to be applied in combination. Late syphilis is generally based on anti-syphilis spirochete treatment, through the injection of benzylpenicillin or procaine penicillin and other anti-syphilis treatment; penicillin allergy, can be treated by oral antibiotic drugs, such as doxycycline. Therefore, there is no need to take oral medication after injection antisyphilis treatment. If the patient is accompanied by heart failure and other complications, generally need to control the heart failure and then antisyphilis treatment, to be compensated for cardiac function, you can start antisyphilis treatment with a small dose of penicillin, and oral drugs to improve cardiac function; if the patient is a neurological syphilis patients, you can inject penicillin antisyphilis treatment at the same time, oral propanesulphonic acid to increase the effect of penicillin. Whether patients with advanced syphilis need to take oral medication after injection, they need to consult the attending doctor and standardize the medication under the doctor’s guidance.