Eating grapefruit headache may be a kind of migraine, migraine is a recurrent headache disease, most patients are distributed on one side, can also appear bilateral pain, often accompanied by nausea, vomiting, a few typical patients may have aura such as visual sensory and motor disorders before the attack. 1, the exact cause is not clear, may be related to genetics, diet, as well as endocrine and mental factors. 2, patients with headache attacks often Some patients may be triggered by noise, odors and certain foods, and some fruits may also induce the onset of the disease. Common foods include mature cheese, pickled products, smoked products, fermented foods and chocolate; 4. Fruits mainly include oranges, oranges and grapefruit. The treatment of the disease is mainly to give symptomatic treatment. Patients with mild cases can take oral paracetamol, ibuprofen and indomethacin; patients with moderate or severe cases can take oral ergotamine caffeine, and also apply zolmitriptan and sumatriptan treatment.