Rheumatoid factor how much more serious can not be generalized, generally more than the normal range, suggesting that the patient has autoimmune disease may be, the higher the rheumatoid factor, the more serious the condition. Under normal circumstances, the normal value of the rheumatoid factor is 0~20IU/ml, the elderly population may appear rheumatoid factor elevation, but relatively speaking, the magnitude of the increase is not large, the rheumatoid factor increase in the pathology of the situation is relatively more, the most common autoimmune system diseases, such as rheumatoid arthritis, dermatomyositis, dry syndrome. When there is a significant increase in the number of rheumatoid factor, it is first necessary to rule out the existence of rheumatoid immune system diseases, and it is recommended that patients need to undergo antinuclear antibody, C-reactive protein, blood sedimentation, and anticitrullinated wave protein antibody, etc., to assess the existence of autoimmune system diseases, and in particular, to rule out the existence of rheumatoid arthritis. In the clinic with increased rheumatoid factor levels, it is recommended to consult the rheumatology and immunology departments of regular hospitals for diagnosis and treatment.