Chronic obstructive pulmonary disease (COPD) is characterized by dyspnea, chronic cough and sputum, wheezing and chest tightness, and may be combined with a variety of other diseases. 1. Dyspnea: Chronic inflammation in COPD can damage the alveoli and affect the gas exchange function, thus causing dyspnea. 2. Chronic cough and sputum: Chronic obstructive pulmonary disease (COPD) causes the airways to become swollen, thickened, and lose elasticity, so that gases can’t pass through the airways and cause coughing. At the same time, COPD is a chronic inflammatory response, if it causes bacterial or viral infections, coughing and sputum may occur. 3. Wheezing and chest tightness: In the late stage of chronic obstructive pulmonary disease (COPD), there may be a loss of lung function, resulting in respiratory failure, wheezing and chest tightness. 4. Other symptoms: Chronic obstructive pulmonary disease can be combined with a variety of diseases: cardiovascular disease (hypertension, coronary heart disease, heart failure, arrhythmia, peripheral vascular disease), diabetes mellitus, lung cancer, osteoporosis, anxiety and depression, etc., and once the combination of other diseases, the corresponding clinical manifestations may appear. If there is an increase in the amount of sputum, purulent sputum, and worsening of dyspnea in chronic obstructive pulmonary disease, acute exacerbation of chronic obstructive pulmonary disease is considered, and it is recommended that hospitalization and timely treatment are recommended.