Gestational toxemia (Pre-eclampsia), also known as pre-eclampsia and prenatal eclampsia, is an increase in blood pressure (gestational hypertension), combined with proteinuria and edema, that occurs in pregnant animals during pregnancy. Pregnancy toxemia is a series of symptoms, not from a single causative agent, and there are many different possible causes of this condition. It can be caused by a substance that enters the pregnant woman’s body through the placenta and causes abnormalities in the endothelial tissue of her blood vessels. The high blood pressure it causes may cause damage to endothelial cells, kidneys and liver; thus causing vasoconstriction factors to be released into the blood vessels, creating secondary damage. If the pregnant animal develops systemic spasms as a result, it is called eclampsia. At the beginning of the disease, the sheep lose appetite, become depressed, stay away from the herd, move restlessly, and have an unsteady gait; the mucous membranes become pale, and as the disease progresses, the pupils become dilated, the vision is diminished, the visible mucous membranes become yellow, and the eyes are dull and stare; in severe cases, the appetite is lost, the head is tilted to the side, the ears tremble, the eye muscles contract, the teeth are clenched, the heart rate increases, the breathing is difficult, and the sheep die in a coma. Prevention of pregnancy toxemia in sheep? Supplementary feeding: Strengthen supplementary feeding in the late pregnancy period of ewes, with 0.6 to 0.8 kg of concentrate and 1 to 1.5 kg of green hay per day per ewe, and reduce the amount of silage fed. At the same time, pay attention to supplemental feeding of carrots, salt and bone meal, adjust the ratio of calcium, phosphorus and other minerals, prohibit the feeding of moldy, rotten, deteriorated and frozen feed, and require that the volume of the feed fed be small and of good quality. Care: Let ewes move properly during pregnancy, with slow and steady movements to prevent crowding, pressing, biting, bumping, leaping, hitting and kicking; prohibit capturing, startling the flock or pumping cold whips for no reason. Conduct regular blood and urine ketone checks on pregnant sheep 1 to 2 days before delivery for early detection and timely treatment. Treatment of pregnancy toxemia in sheep Protect the liver and lower blood ketones: use Unocal oral solution and let sick sheep take 1 bottle each time, 2 times a day. Promote metabolism: use Biling injection intramuscularly (0.1-0.2 ml per kg body weight of sheep) or saline diluted (at a ratio of 1:10) and then drip slowly. Prevention and treatment of acidosis: give the sick sheep a sedative injection of 100 ml of 5% sodium bicarbonate solution once a day for 3 days. Prevention of secondary infections: Inject the sheep with a mixed injection of 0.1 ml per kg of body weight (0.1 ml per kg of body weight) and inject the sheep with 0.1 ml per kg of body weight (0.1 ml per kg of body weight), respectively, intramuscularly for 2 to 3 days. Strengthen care: Feed green hay, carrot, alfalfa, etc., and feed multi-flavored stomachic to enhance appetite; let sick sheep exercise properly to promote recovery. If the condition deteriorates and endangers the life of ewes and lambs, a comprehensive examination should be conducted; if it reaches the delivery date, artificially assisted delivery or caesarean section can be performed; if it does not reach the delivery date, the pregnancy should be terminated in time.