Toothache is the main symptom of endodontic periapical disease, and pericoronitis of wisdom teeth can also cause toothache and usually requires immediate pain relief. For quick pain relief, emergency treatment such as incision and drainage of pus, removal of irritation, and anti-inflammatory and analgesic treatment can be used in the initial treatment. 1. Incision and drainage: If periapical periodontitis leads to subperiosteal or submucosal abscess formation, local anesthesia should be applied before incision and drainage to relieve toothache. 2. Remove the irritation: For apical periodontitis caused by root canal trauma and chemical irritation, the irritant should be removed, the root canal should be rinsed repeatedly, and the root canal should be re-sealed with medication or aseptic cotton twists to avoid re-infection. 3. Anti-inflammatory and pain relief: generally, oral painkillers such as ibuprofen, loxoprofen sodium tablets can be used, or antibiotic drugs such as metronidazole, ornidazole, etc., or local closure can be used. Emergency treatment can not cure toothache, caused by toothache factors are complex and diverse, it is recommended that patients seek medical attention in a timely manner to identify the cause of the disease, the cause of the treatment, the use of drugs need to comply with the doctor’s instructions.