The most common cause of heartburn at night is gastroesophageal reflux, which manifests itself mainly as a burning or feverish sensation, sometimes painful, in the glabella or retrosternal area. It can also be seen in bile reflux gastritis, Barrett’s syndrome, non-ulcer dyspepsia, pediatric vomiting, peptic ulcers, etc. The first thing to do is to treat the cause, usually with a combination of acid suppressants and prokinetic drugs or mucosal protectors, and also to change the composition and habits of the diet, do not eat too much, avoid coffee, strong tea and other beverages, and do not eat before bedtime. It is also necessary to exclude cardiac lesions, sometimes angina can be manifested as the above symptoms, so when the above symptoms appear, improve the electrocardiogram examination in time to exclude cardiomyopathy and avoid delaying the disease.