High dfi can do second generation IVF. The second generation IVF is an intracytoplasmic single sperm injection technique, in which the male semen is removed and processed, and then a single sperm is sucked up and injected directly into the cytoplasm of the female egg cell using a syringe, helping the sperm and egg to combine and differentiate to form an embryo. The second generation of IVF is mainly applied to the eggs can not be naturally fertilized, through artificial technology to assist fertilization. High male dfi indicates high sperm DNA fragmentation rate, sperm quality decreases, may not be able to fertilize the phenomenon, at this time you can take the second generation of IVF to help fertilization, or the first generation of IVF found to be unable to fertilize, and then change to the second generation of IVF. Men with high dfi can be treated before conception to improve sperm quality, and can take folic acid, sperm production tablets and other medications, the specific medication program should be carried out under the guidance of a doctor.