Can female patients have babies after kidney transplantation? Among the population of kidney transplant patients, a considerable part of them are women of childbearing age who have not had children. For them, whether they can have a healthy baby or not becomes an important common topic. Can kidney transplant recipients get pregnant and give birth? In fact, as early as 1958, Murray and other transplant surgeons reported the world’s first case of a successful pregnancy after kidney transplantation, which was subsequently summarized and published in the New England Journal of Medicine, a leading medical journal. Despite the greater risks associated with pregnancy in organ transplant patients, the widespread availability of organ transplantation and the continued increase in patient fertility needs have led to a global accumulation of successful births in female transplant patients. According to statistics, the number of organ transplant patients who have become pregnant and given birth to successful babies has exceeded 15,000 worldwide. Does pregnancy and childbirth have an effect on the transplanted kidney? Pregnancy in kidney transplant patients increases the burden on the transplanted kidney, but whether it has long-term adverse effects on the transplanted kidney is still debated. Current studies have shown that the blood creatinine level, proteinuria level, blood pressure and the interval between transplantation-pregnancy are important factors affecting the prognosis of the transplanted kidney, but under certain conditions, pregnancy itself has no significant effect on the long-term function and survival of the transplanted kidney. Therefore, the timing of pregnancy after renal transplantation is very important. Conditions and timing of pregnancy after kidney transplantation There is no uniform answer to the question of when a female kidney transplant recipient can become pregnant or have a baby after surgery. Currently, it is recommended that pregnancy and childbirth be considered only after 2 years of stable transplanted kidney function. The ideal situation is to maintain the amount of immunosuppression, no signs of rejection, stable graft function, and well-controlled co-morbidities such as hypertension and diabetes. Specifically, the risk of pregnancy is generally considered to be low if the following criteria are met Do you meet the best conditions for childbirth? 1. 2 years after kidney transplantation and in good general condition; 2. no occurrence of transplantation rejection; 3. stable transplantation kidney function with serum creatinine <133 μmol/L; 4. under 30 years of age; 5. normal blood pressure or blood pressure ≤140/90 mmHg when using the smallest dose of antihypertensive drugs (only one antihypertensive drug); 6. proteinuria <500 mg/24 h; 7. transplantation Normal renal ultrasound with hydronephrosis of the transplanted kidney; 8. Immunosuppressive drugs reduced to maintenance doses: prednisone ≤ 10 mg/d, azathioprine ≤ 50 mg/d, cyclosporine A ≤ 3 mg/(Kg.d), but morte-macrolimus and sirolimus are contraindicated (morte-macrolimus and sirolimus should be discontinued 6 weeks prior to planned conception).