At present, the contradiction of donor shortage is becoming more and more prominent worldwide. Kidney transplantation in China mainly comes from cadaveric donor kidneys, but with more than 100,000 new uremia patients every year, cadaveric donor kidneys are far from meeting the needs. Relative-donor kidney transplantation has the advantages of ideal matching, low incidence of rejection, short hot ischemia and cool ischemia time, low postoperative immunosuppressant dosage and relatively low surgical cost, which can be used as an alternative to dialysis for life support. However, it carries certain risks at the expense of a healthy person’s normal kidney, and the country has introduced a series of laws and regulations to regulate living donor kidney transplantation from relatives. Before a kidney donor decides to donate a kidney to your loved one, he/she should be clear about the following: 1. He/she must comply with the law: be at least 18 years old, have full capacity for civil behavior, be the patient’s spouse, blood relatives in the direct line or blood relatives within three generations, and the disabled or mentally retarded people cannot donate organs. 2.Generally speaking, one kidney is enough to fulfill the body’s needs. However, if you are unfortunate enough to suffer from trauma, kidney stones, tumors and other diseases in your future life, you will face greater surgical risks than normal people, and even this only kidney may be forced to be removed, and your unselfishness may lead to uremia, are you prepared for this? 3.Foreign statistics, the mortality rate of kidney donors is about 0.03% (or 3 out of 10,000), but there is no domestic statistics, but there are cases of death and other serious complications. 4.Your kidney is not guaranteed to survive permanently in the recipient’s body, you have to be able to accept this reality. Recipients should have the following considerations before deciding to have a living kidney transplant from a relative: 1. Living kidney transplant is not the only option, hemodialysis, peritoneal dialysis and cadaveric kidney transplants are all good alternatives. 2. Living kidney transplantation is also subject to rejection and infection, leading to nephrectomy and death. Chronic rejection can also occur, leading to gradual loss of function of the transplanted kidney and a return to dialysis. 3. Despite the availability of advanced immunosuppressive drugs, it is not possible to absolutely avoid hyper-acute rejection rebirth (which can lead to the removal of the transplanted kidney), and even parents donating kidneys to their children are not an exception. 4, Although there are statistics showing that the long-term survival rate of living relative transplantation is higher than that of cadaveric donor kidney, the final survival rate for an individual is also affected by a variety of factors, such as the age of the donor, the quality of the donor kidney, and the patient’s compliance after the operation. After careful consideration, please go to the local police station to issue a certificate of kinship, and go to a notary public for impartiality, and bring both donor and recipient’s ID cards and household registration books to the hospital for HLA matching and comprehensive physical examination. After passing the hospital’s ethical meeting, you have to wait for approval from the higher health administrative department, and this time usually takes several months. Finally, in order to ensure the safety of the donor and recipient, please go to a large transplant center with transplant qualification for living kidney transplant. Respectfully, organ trading is illegal and organ donation from non-relatives is eliminated!