Symptoms of advanced stage of glioma in the brain mainly focus on headache, numbness and weakness of limbs, speech dysfunction, impaired consciousness, seizure, and impaired consciousness. 1. Intermittent headache may occur, which cannot be completely relieved by general painkillers, and the headache is recurrent and gradually aggravated, which is the most common clinical symptom. 2. With the gradual growth of glioma, the important functional areas will be compressed, and numbness and weakness of limbs and impaired speech will gradually appear, which will gradually cause patients to lose their ability to work and take care of themselves, and eventually form a long-term bed-ridden state. 3. Glioma may disrupt the normal firing process of the cerebral cortex and induce seizures, or even persistent epileptic seizures in the late stage. 4. Most of the patients will have recurrent vomiting, projectile vomiting and inability to eat in the late stage. In addition, there will be consciousness disorders, such as drowsiness, lethargy or even coma, which may cause respiratory and cardiac arrest and death. In conclusion, the condition of advanced glioma is more serious, and should be treated according to the doctor’s advice.