The clinical manifestations of bone cancer are firstly, painful sensation at the lesion site, and swelling or palpable lump at the lesion site, and in severe cases, it may also lead to dysfunction at the lesion site, as well as compression symptoms, bone deformity, pathological fracture, etc. Further development may also lead to systemic symptoms. Pain is the earliest clinical symptom of bone cancer and certainly the main symptom, which is relatively mild and intermittent at first, but with the further development of the disease, the pain will gradually increase and even develop into persistent. If the lump is under the periosteum, or if the tumor is relatively early, and if the bone cancer is superficial, swelling and deformation of the bone can be palpated. In the later stage of bone cancer, because of swelling and pain, the function of the tumor area will be limited and even lead to muscle atrophy. The pressure of the tumor on the cranial cavity and nasal cavity is also possible, because especially the cranial cavity, which is a relatively closed cavity, if the tumor grows inward, the compression symptoms will be more obvious and the patient will experience intracranial hypertension and even lead to other symptoms related to the nervous system. If the tumor grows inward, the compression symptoms will be more obvious and the patient will experience intracranial hypertension, even leading to other symptoms related to the nervous system. If the tumor develops further, it may lead to many systemic symptoms, such as cachexia, anemia, mental depression and so on.