Current findings show that folic acid deficiency and/or defects or gene mutations in key enzymes in the Hcy/folic acid metabolic pathway are the main causes of elevated blood Hcy levels.In 2016, China issued the Expert Consensus on the Diagnosis and Treatment of H-type Hypertension.Combining the consensus and some of the country’s own research, let’s talk about the concepts of the treatment of H-type hypertension. Pharmacological treatment 1, folic acid For H-type hypertension patients without cardiovascular and cerebrovascular disease, it is recommended that folic acid be supplemented jointly on the basis of antihypertensive treatment; for patients with cardiovascular and cerebrovascular disease the same recommendation is made, and it is recommended that antihypertensive drugs containing 0.8mg of folic acid in a fixed compound preparation be recommended; if the blood pressure can not be reached after the use of the fixed compound preparation, it is possible to use other kinds of antihypertensive drugs jointly, until the blood pressure reaches the standard. The results of the meta-analysis suggest that folic acid supplementation for >3 years can reduce the risk of stroke, while patients in the China Primary Prevention of Stroke Study (CSPPT) have been taking it for 4.5 years, showing good effectiveness and safety. 2.Atorvastatin High-dose atorvastatin (40mg/night) can reduce homocysteine level, improve endothelial function, inhibit inflammatory response and improve therapeutic effect compared with conventional dose (20mg/night). 3.Methylcobalamin Methylcobalamin, also known as methyl vitamin B12, as a subtype of vitamin B12 has the advantages of fast absorption, body storage time, high utilization rate. High Hcy blood is an important factor causing diabetic peripheral neuropathy (DPN), methylcobalamin treatment of DPN can significantly reduce plasma Hcy level, improve nerve conduction velocity and clinical symptoms. 4, Vigilantin Vigilantin for the treatment of type 2 diabetes mellitus has a good clinical effect, not only can effectively improve the blood glucose indicators, and good safety, low rate of adverse reactions, but also reduce the expression level of serum CRP, HCY, which to a certain extent can reduce the occurrence of vascular complications of diabetes mellitus. Lifestyle intervention 1, exercise Animal experiments show that: for different intensity exercise intervention, serum Hcy level from high to low is folic acid group > low intensity group > medium intensity group > high intensity group (P < 0.05), which indicates that appropriate exercise, especially medium and high intensity exercise can effectively prevent the plasma Hcy level from rising due to excessive methionine intake, and its effect is better than taking folic acid. Clinical studies have shown that 12 weeks of moderate-intensity aerobic exercise can effectively reduce the blood Hcy level of patients with H-type hypertension, reduce the morning peak blood pressure and blood pressure volatility, and reduce the frequency of abnormally elevated blood pressure, which is better than the effect of single drug treatment. 2, diet Folic acid is a kind of B vitamin stored in green vegetables, the earliest extracted from plant leaves, so named folic acid. Diet if long-term large amount, excessive intake of animal protein and not timely supplementation of adequate amount of vitamins and folic acid lead to HCY content increased. Therefore, it is recommended to consume foods rich in folic acid and B vitamins, such as animal liver, kidney, fish, shellfish, dairy products, etc., plant mushrooms, citrus, broccoli, nuts, grains, potatoes, tomatoes, fruits, soybeans, spinach, lettuce, lentils, coarse grains and so on. Folic acid heat, light, acid is not stable, in cooking folic acid activity can be lost 50-90%, salt water-soaked vegetables folic acid composition loss is also very large. Therefore, it is recommended that green leafy vegetables and fruits be eaten raw. It is not advisable to use hot water to pan the rice; porridge do not add alkali; frying vegetables in a hurry when the fire quickly fried 3 to 5min can be; cooking vegetables should be boiled water and then put vegetables and time can not be too long and so on, in order to prevent the loss of folic acid.