The cause of rib pain due to pleurisy may be the irritation of the intercostal nerves by pathogens and inflammatory substances as well as pleural fluid. Inflammatory response of pleura, on the one hand, because of pathogens and corresponding inflammatory substances directly stimulate the pleura and intercostal nerve triggered pain, on the other hand, the pleural capillaries hydrostatic pressure increases, pleural permeability increases and so on to produce pleural effusion, its exudate or leakage of fluid can cause fever, chest pain, dry cough and other symptoms, but also can be stimulated to the intercostal nerve and cause rib pain. There are many causes of pleurisy, including congestive heart failure, invasion of the pleura by malignant tumors, and infections caused by pathogens, such as Staphylococcus aureus, Streptococcus pneumoniae, Mycobacterium tuberculosis, etc., which need to be treated according to the cause of the disease, and it is recommended to consult a doctor in time.