People with diabetes often suffer from foot complications. Worldwide, people with diabetes are 15 to 20 times more likely to develop foot problems than the rest of the population. Foot disease may occur in 15% of diabetic patients, and 85% of amputations are due to foot ulcers. The development of diabetic foot is mainly due to patients with long-term diabetes, high blood glucose, resulting in lipid metabolism disorders and thus easy to cause arterial lumen narrowing, occlusion. At the same time, the high blood sugar state will cause the human microvascular wall degeneration and thickening, lumen narrowing and occlusion, resulting in lower limb tissue ischemia and hypoxia. Due to the large blood vessels and microvascular lesions, causing neurotrophic disorders and ischemic neuritis, so that the body lacks of protective measures for the foot (because of the weakening or loss of protective sensations in the endings of the limbs), which is very easy to cause physical injury. Once the foot is damaged in diabetic patients, due to low immunity, neuropathy and peripheral vasculopathy, tiny trauma can cause microbial invasion and infection, and the high glucose state of diabetic patients provides rich nutrients for bacterial growth and reproduction, thus making the infection easier to spread. Pathophysiological changes also make it difficult to repair and control the infection, which finally develops into foot gangrene as a result of the joint action of the above factors. For diabetic foot patients who have not developed ulcers in the early stage, they should do a good job in foot protection and nursing, avoiding foot trauma; once patients are troubled by serious diseases such as foot ulcers or even gangrene, they need to be treated in time to promote the timely healing of the ulcerated parts. Our department adopts advanced PRP technology and masquelet technology, and has achieved good therapeutic effect. Difficult-to-heal wounds are commonly known as ulcers, also called chronic wounds. Difficult-to-heal wounds include diabetic foot, decubitus ulcers, vascular ulcers of the lower limbs, radioactive ulcers, scar ulcers, sinus tracts, wounds caused by various traumatic injuries and surgeries, and residual wounds from large-area and deep burns in the late stage, etc. Difficult-to-heal wounds have gradually become one of the serious complications threatening the patient’s survival and quality of life.