Calf vein thrombosis refers to the thrombosis of the intermuscular plexus of the calf, which can be treated with medication, and severe patients can undergo surgery or intervention to remove the embolism. 1.Medication: including anticoagulant drugs, thrombolytic drugs and symptomatic drugs. Anticoagulation is the basic treatment, regardless of the stage of deep vein thrombosis, anticoagulation is very important; anticoagulants include heparin, low molecular heparin, warfarin and new anticoagulant drugs. If the amount of deep vein thrombosis is large or has involved the iliac vein or inferior vena cava, thrombolytic treatment is needed; thrombolytic drugs include urokinase, fibrinolytic enzyme, tissue-type fibrinogen activator (t-PA), etc.; if there is severe pain and swelling, intravenous active drugs can be given for treatment. 2.Surgical treatment: namely, incision and embolization, which has certain risks and a relatively high chance of recurrence and is less used clinically; 3.Interventional treatment: namely, endovascular treatment, including catheter thrombolysis, catheter aspiration or crushing treatment. 4.General treatment: bed rest and reduced activity; at the same time, the lower limbs are elevated, making them higher than the heart level to improve venous return and reduce edema and pain. Elastic stockings are suitable for thrombosis for more than 2 weeks, and the condition enters the chronic stage. The treatment of thrombosis of the intermuscular plexus in the calf varies according to the acute and chronic stage of the disease, and a treatment plan should be developed for each case.