A very small number of liver fluke infections may resolve spontaneously if the body’s immune system is functioning properly, but in the vast majority of cases patients will present with a chronic infection that does not usually resolve spontaneously. After humans consume fish infected with liver fluke, the adult parasites become parasitized in the bile ducts of the liver. Since the immune system is not specific for the parasite, the adult parasites will continuously destroy the epithelium of the bile ducts and submucosal blood vessels to induce varying degrees of hypersensitivity and inflammatory reactions, which in turn will continuously damage the bile ducts and liver. However, the number of infected liver fluke is very small. Within the body’s tolerance range, the body’s immunity can gradually clear the parasite. There is a possibility of self-healing. However, if the number of parasites is large or the body’s immunity is low, liver fluke infection usually manifests itself as chronic symptoms, that is, it often takes several years for the patient to gradually develop clinical symptoms, such as fatigue, epigastric discomfort, loss of appetite, vague pain in the liver area, etc. In this case, the patient will not be able to recover from the infection. In this case, the patient cannot be cured by himself and needs active treatment. Once chronic parasitic infection or serious infection occurs, deworming treatment is needed in time, such as praziquantel and albendazole can be taken according to the dosage under the guidance of the doctor. Avoid delayed treatment resulting in adverse consequences.