Waking up with toe pain can be caused by improper sleeping position, cold, muscle injury and other reasons. 1. Improper sleeping position: If you keep a position for a long time at night, compressing the local blood vessels of the toes, resulting in insufficient local blood supply, the symptoms of waking up with toe pain will appear. 2. Cold: at night when sleeping, the patient is in a cold space or not covered with a good blanket, resulting in a slowdown in local blood circulation, metabolites in the local accumulation, the symptoms of waking up with toe pain may occur. 3. Muscle damage: If the toe muscle is damaged due to overwork during the day, toe injury or shoe squeeze, the uric acid content in the body will be too high, leading to the symptom of waking up with toe pain. Because of the many causes of waking up with toe pain, it is recommended to go to the hospital in time for examination and diagnosis, and to give regular treatment after clarifying the cause of the disease.