High urinary bilirubin is mostly due to liver and biliary tract diseases, portal vein lesions, genetic disorders, etc., causing bilirubin metabolism disorders, and it is recommended to combine with urobilinogen, urobilin and other tests to make a comprehensive judgment.
1. Liver and biliary tract diseases: such as acute jaundice hepatitis, obstructive jaundice, etc., which can lead to high urinary bilirubin.
2. Portal vein diseases: such as periportal inflammation, fibrosis, etc. When the patient is bilious due to periportal inflammation and fibrosis, it can lead to elevated urinary bilirubin.
3. Genetic disorders: Some chromosomal genetic disorders can lead to congenital hyperbilirubinemia, such as Dubin-Johnson syndrome and Rotor syndrome, etc., all of which can cause urinary bilirubin to varying degrees of increase.
Clinically, it is not recommended to look at certain test results in isolation. In case of elevated urinary bilirubin, it is recommended to combine the results of urine bilirubin, urobilinogen, urobilin, liver function, serum bilirubin, etc. to comprehensively judge and analyze the results, to find out the cause of the disease as soon as possible, and to give targeted treatment.