Timosartan is not recommended to be taken with captopril. Timosartan is an ARB drug, while captopril is an ACEI drug, due to the similarity of the antihypertensive effect or antihypertensive mechanism of these two types of drugs, the combined application may increase the adverse effects of the drug, so ARB drugs and ACEI drugs are not recommended to be used in combination. It should be noted that the use of timosartan is prohibited for those who are allergic to the active ingredient of timosartan and any one of the excipient components, mid- to late-stage pregnancy, lactating women, children under 18 years of age, those with biliary obstructive disease and those with severe hepatic impairment, and the patient may experience diarrhea, nausea, dizziness, and other adverse reactions after taking the drug. Captopril is prohibited for those who are allergic to captopril or other angiotensin-converting enzyme inhibitors and pregnant women, and patients may experience adverse reactions such as rash, palpitations and cough after taking it. Patients with high blood pressure should take medication under the guidance of a doctor, do not take medication without authorization to avoid delaying the condition.