The pain in the palm of the hand can not clench the fist may be related to hand infection, trauma, degenerative arthritis and so on. 1. Hand infection: when the hand skin, muscles, tendons and other soft tissues are infected by bacteria, fungi and other infections, there can be symptoms of hand swelling, pain, accompanied by redness of the skin, fever, and in severe cases, it can be manifested as systemic symptoms, such as fever. 2. Trauma: when the hand is smashed, crushed and other traumas, it can lead to muscle congestion and edema, causing pain in the palm of the hand and not able to clench the fist, which can cause serious fracture, and can be accompanied by skin bruising, pain, deformity and other symptoms. 3. Degenerative arthritis: various causes of degeneration, degeneration, wear and tear, disappearance of articular cartilage can lead to complete destruction of the joint surface, deformity, so that the patient appears to have pain in the palm of the hand clenched fist symptoms. Hand pain clenched fist can also be caused by other reasons, it is recommended to go to the hospital in a timely manner, for effective treatment, so as not to cause adverse effects.